N-Acetyl Selank Amidate
Modified Selank — Enhanced Intranasal Stability
N-acetylated, C-amidated variant of the Semax-family nootropic Selank, designed for intranasal stability. Available in 10 mg and 30 mg.
Cognitive & Nootropic
Category
From $71.99
Price
Research
Grade
Price
From $71.99
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Suggested Protocol
Intranasal protocols use 2–3 drops per nostril of reconstituted solution delivering 150–300mcg per administration, one to three times daily. Research arms are typically 2–4 weeks with anxiolytic endpoints (open-field or elevated-plus-maze in rodent models; STAI scales in human research reference designs).
Selank was developed at the same Moscow institute that produced Semax, using the same design strategy applied to a different endogenous fragment: a synthetic analog of tuftsin — the immunomodulatory tetrapeptide (Thr-Lys-Pro-Arg) cleaved from IgG heavy chain — extended with a C-terminal tripeptide (Pro-Gly-Pro) to stabilize it against proteolysis. The final sequence is Thr-Lys-Pro-Arg-Pro-Gly-Pro, and its clinical development targeted anxiolytic use without the cognitive and motor side effects of benzodiazepines.
Tuftsin Heritage
From IgG Cleavage Fragment to Anxiolytic Research Tool
Tuftsin is the immunomodulatory tetrapeptide released from IgG Fc by leukokininase. Selank extends that sequence with a Pro-Gly-Pro proteolytic-shield tripeptide, which is what makes the molecule stable enough for CNS research. The tuftsin heritage ties Selank into immune-CNS crosstalk biology as much as into classical anxiolytic pharmacology.
Three-Layer Stability
Why This Variant Has the Longest Half-Life of Any Selank Form
Base Selank uses the internal Pro-Gly-Pro motif to resist proteolysis. NA-Selank Amidate adds both terminal protections on top — N-acetyl against aminopeptidases, C-amide against carboxypeptidases. That triple-layer design is the pharmacokinetic reason this variant is selected over plain Selank for extended research protocols.
Distinct From Semax
Different Pathways Despite Same Lab Origin
Both Semax and Selank came from the same Moscow institute's peptide-engineering program, but they target different pharmacology. Semax is BDNF/NGF-modulating, Selank is GABAergic/enkephalinergic. Protocols should be built around their separate mechanisms rather than treated as class-interchangeable tools.
Documented Effects
Stability-optimized variant of the tuftsin-derived Moscow Selank heptapeptide
Three layers of proteolytic protection: N-acetyl, C-amide, and internal Pro-Gly-Pro
Anxiolytic research signal comparable to benzodiazepines in published rodent data
Distinct from Semax — GABA/enkephalin modulation rather than BDNF/NGF pathway
Intranasal route exploits olfactory and trigeminal CNS access
10mg vial supports short-arm intranasal research at standard cadences
Specifications
| Product | N-Acetyl Selank Amidate |
|---|---|
| Category | Cognitive & Nootropic |
| Format | Lyophilized powder |
| Price | From $71.99 |
Complementary Compounds
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From $71.99
✓ 10% off via PeptidesMuscle
Administration Outline
Intranasal protocols use 2–3 drops per nostril of reconstituted solution delivering 150–300mcg per administration, one to three times daily. Research arms are typically 2–4 weeks with anxiolytic endpoints (open-field or elevated-plus-maze in rodent models; STAI scales in human research reference designs).
N-Acetyl Selank Amidate — FAQs
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Selank 10mg
Selank 10mg — the unmodified Thr-Lys-Pro-Arg-Pro-Gly-Pro heptapeptide from the original Moscow Institute publications, supplied without the N-acetyl or C-amide stability modifications of the amidate variant.
