MOTS-c
Mitochondrial-Derived Peptide (MDP)
16-residue peptide encoded by the 12S rRNA region of mitochondrial DNA. Studied for metabolic homeostasis and exercise-response modulation. Available in 10, 20, and 40 mg sizes.
Anti-Aging & Longevity
Category
From $116.99
Price
Research
Grade
Price
From $116.99
✓ 10% off via PeptidesMuscle
Suggested Protocol
Published animal and pilot-research protocols use 5–10mg subcutaneously per week, often split across 2–3 dosing days. The 10mg vial accommodates roughly 2–3 weeks of research at the lower end of that cadence or 1 week at the upper end.
MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded within the 12S ribosomal RNA gene of mitochondrial DNA — MRWQEMGYIFYPRKLR. Pinchas Cohen's group at USC reported the peptide in 2015, and the finding was significant because it established that mitochondrial DNA encodes functional signaling peptides, not only respiratory-chain subunits.
Available Sizes
Specifications
| Product | MOTS-c |
|---|---|
| Category | Anti-Aging & Longevity |
| Format | Lyophilized powder |
| Price | From $116.99 |
Reported Endpoints
First functional peptide identified from within a mitochondrial DNA rRNA locus
Activates AMPK indirectly via folate-cycle inhibition and AICAR accumulation
Translocates to nucleus under metabolic stress as a transcriptional co-regulator
Plasma levels decline with age and insulin resistance in human cohort data
Published research includes glucose homeostasis and exercise-physiology endpoints
Sequence MRWQEMGYIFYPRKLR is the full 16-residue active peptide
Dosing Guide
Published animal and pilot-research protocols use 5–10mg subcutaneously per week, often split across 2–3 dosing days. The 10mg vial accommodates roughly 2–3 weeks of research at the lower end of that cadence or 1 week at the upper end.
MOTS-c — FAQs
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