SS-31 (Elamipretide)
Mitochondria-Targeted Tetrapeptide
D-Arg-dimethyl-Tyr-Lys-Phe-NH₂ — a cationic peptide that concentrates in the inner mitochondrial membrane and binds cardiolipin. Available in 10, 25, and 50 mg.
Anti-Aging & Longevity
Category
From $89.99
Price
Research
Grade
Price
From $89.99
✓ 10% off via PeptidesMuscle
Suggested Protocol
Published clinical protocols of elamipretide use 40 mg subcutaneously once daily in Barth syndrome and mitochondrial myopathy trials. Research replication studies typically start at the lower published doses and adjust by body weight. A 10mg vial is sized for mechanistic or short-duration work rather than full-dose clinical mimicry.
SS-31 — developmental name elamipretide, patent-series "Szeto-Schiller 31" — is a four-residue peptide engineered for a single, unusual trick: it accumulates a thousand-fold at the inner mitochondrial membrane by forming a non-covalent association with cardiolipin, the dimeric phospholipid that organises cristae and anchors electron-transport supercomplexes. Most peptides cannot reach mitochondria at all. SS-31 reaches them preferentially, and once there it stabilises cardiolipin under oxidative stress and preserves cristae architecture that would otherwise collapse during ischaemia, ageing, or genetic cardiolipin-remodelling defects.
Available Sizes
Specifications
| Product | SS-31 (Elamipretide) |
|---|---|
| Category | Anti-Aging & Longevity |
| Format | Lyophilized powder |
| Price | From $89.99 |
Reported Endpoints
Cardiolipin-targeting — the only peptide class that concentrates at the inner mitochondrial membrane by design
Preserves cristae architecture under oxidative and ischaemic stress
Reduces mitochondrial ROS generation without blocking the electron-transport chain itself
Stabilises electron-transport supercomplex assembly where cardiolipin is remodelled or oxidised
Advanced into phase 3 by Stealth BioTherapeutics (Barth syndrome, mitochondrial myopathy) — a level of clinical validation rare among research peptides
D-Arg and dimethyl-Tyr residues confer protease stability that native tetrapeptides lack
Best Stacked With
Research Protocol
Published clinical protocols of elamipretide use 40 mg subcutaneously once daily in Barth syndrome and mitochondrial myopathy trials. Research replication studies typically start at the lower published doses and adjust by body weight. A 10mg vial is sized for mechanistic or short-duration work rather than full-dose clinical mimicry.
SS-31 (Elamipretide) — FAQs
Related Anti-Aging & Longevity Research
View All
MOTS-c
16-residue peptide encoded by the 12S rRNA region of mitochondrial DNA. Studied for metabolic homeostasis and exercise-response modulation. Available in 10, 20, and 40 mg sizes.
Methylene Blue 10mg/mL 50mL
Methylene Blue 10mg/mL 50mL — the oldest synthetic pharmaceutical still in clinical use (Ehrlich, 1880s), a phenothiazine redox dye explicitly not a peptide, studied for mitochondrial electron-transport bypass and cognitive-bioenergetics research.
